Captain Rory Best and Johnny Sexton are among 12 changes to the Ireland team to face Argentina as Joe Schmidt reverts to a more familiar line-up.
An experimental side dismantled Italy 54-7 last week in Chicago, but hat-trick hero Jordan Larmour is one of only three players to keep his place as the Six Nations Grand Slam champions return to Dublin.
While Jacob Stockdale and Bundee Aki also remain, several big names return, led by Best in an all-new forward pack. Cian Healy and Tadhg Furlong are also in the front row.
World Rugby Player of the Year nominee Sexton replaces Joey Carbery at fly-half. Centre Garry Ringrose is out with injury as Robbie Henshaw comes back in.
Larmour's continued opportunities at full-back come partially due to the absence of Rob Kearney.
Argentina coach Mario Ledesma has named a XV made up entirely of home-based players.
Guido Petti moves into the Pumas back row, while Santiago Medrano earns just his second Test start.
Ireland XV to play Argentina: Jordan Larmour, Keith Earls, Robbie Henshaw, Bundee Aki, Jacob Stockdale, Johnny Sexton, Kieran Marmion; Cian Healy, Rory Best, Tadhg Furlong, Iain Henderson, James Ryan, Peter O'Mahony, Sean O'Brien (Leinster), CJ Stander (Munster).
Replacements: Sean Cronin, Jack McGrath, Andrew Porter, Devin Toner, Dan Leavy, Luke McGrath, Joey Carbery, Andrew Conway.
Argentina XV to play Ireland: Emiliano Boffelli, Bautista Delguy, Matias Orlando, Jeronimo de la Fuente, Ramiro Moyano, Nicolas Sanchez, Tomas Cubelli; Santiago Garcia Botta, Agustin Creevy, Santiago Medrano, Matias Alemanno, Tomas Lavanini, Pablo Matera, Guido Petti, Javier Ortega Desio.
Replacements: Julian Montoya, Juan Pablo Zeiss, Lucio Sordoni, Rodrigo Bruni, Tomas Lezana, Gonzalo Bertranou, Joaquin Diaz Bonilla, Matias Moroni.
|Pliskova saves four match points to stun Serena with comeback win|
|Anthony ´can only make´ a team better, says Iverson|
|Henry more worried about Monaco´s future than his own|
|Osaka powers past Svitolina in Melbourne|
|Harden on Anthony trade: It kind of sucks that it didn´t work out|
|Redskins remain ´optimistic´ QB Alex Smith will play again|
|Patriots coach Belichick says Rams´ Donald is ´pretty much unblockable´|
|PSG fined €100,000 by LFP over player-recruitment practices|
|I´m not his father - Guardiola demands Mendy matures|
|Sykes record in vain as Banvit claim victory|
|Usain Bolt calls time on football career|
|Otamendi not happy at Man City, says Guardiola|
|Workaholic Woods learning to rest as he prepares for 2019 debut|
|Henry´s Monaco dumped out of Coupe de France|
|Qatar can win Asian Cup, says Sanchez|
|Tim Howard to retire following 2019 MLS season|
|Koscielny backs Bellerin to return from injury ´stronger than before´|
|Chiefs fire DC Bob Sutton after AFC Championship loss to Patriots|
|Reyes returns to Spain with second-tier strugglers Extremadura|
|Emiliano Sala: Profile of Cardiff City striker missing after joining from Nantes|
|Messi rested for Sevilla trip, Boateng set for debut|
|Nuno fined over pitch celebration in Leicester win|
|Nadal unfazed by another Next Gen opponent in Tsitsipas|
|Ulster hand lifetime ban to spectator after Zebo abuse|
|Phehlukwayo´s career-best day inspires Proteas against Pakistan|
|Bournemouth pounce for Brentford´s Mepham|
|You say all signings are controversial – Valverde defends Boateng arrival|
|Search for missing Sala plane suspended|
|Kohli and Williamson display mutual respect as India and Black Caps prepare for battle|
|Qatar 1 Iraq 0: Al Rawi free-kick books quarter-final spot|
|Ba joins Adebayor and Robinho at Istanbul Basaksehir|
|BREAKING NEWS: Tottenham´s Alli out until March with hamstring injury|
|Fit-again Joseph added to England squad|
|It is very, very serious for us - Tuchel wants midfielder in January window|
|Lakers expect Rajon Rondo back Thursday as LeBron James continues rehab|
|Atletico Madrid boosted as Koke thigh injury revealed to be minor|
|South Korea 2 Bahrain 1 (after extra time): Kim Jin-su seals quarter-final spot|
|AC Milan confirm Zapata thigh injury|
|I miss him a lot - Guardiola confirms ´clever´ Mendy back in Man City squad|
|Tiafoe wants LeBron meeting after run to Australian Open quarters|
|Cardiff continue to ´pray´ for Sala|
|West Ham fined over Burnley clash chaos|
|Knicks star Enes Kanter frustrated by reduced role|
|Kvitova getting back to her best, says Barty|
|Kvitova revels in first semi of ´second career´|
|Messi´s the best player in every world – Boateng dismisses past Real Madrid comments|
|Thunder frustrations continue against Renegades|
|Alonso vows to clear name in tax fraud case|
|Classy Nadal downs Tiafoe to set up Tsitsipas semi|
|Hoedt leaves Southampton for Celta Vigo on loan|
|Melbourne City 4 Western Sydney Wanderers 3: Hosts edge thriller with two goals in last six minutes|
|Wilder won´t even pick up the phone - Hearn not hopeful of AJ bout|
|Sala was on board missing plane, say French authorities|
|Arsenal´s Bellerin out for season with ACL rupture|
|Gatland waiting on ´concrete´ offers|
|Ronaldo accepts prison sentence and €18.8m fine for tax fraud|
|Tsitsipas: It was vital to back up Federer win|
|Awesome Kvitova ends Barty´s home run in Melbourne|
|CA rejects Thunder appeal for full points in abandoned Heat clash|
|Emiliano Sala: Concerns grow for Cardiff striker after plane goes missing|
|Harden unimpressed with refs in Rockets´ 76ers disappointment|
|Ronaldo arrives for sentencing in tax fraud case|
|Record-breaking evening ´one of those nights´ for Warriors star Thompson|
|Hazard still interested in Real Madrid but won´t rule out Chelsea stay|
|Collins moves past Pavlyuchenkova, into Australian Open semis|
|Kohli makes history with ICC awards sweep|
|Thompson sets NBA record with 10 straight made three-pointers to open game|
|76ers hand Rockets largest loss of season, Harden scores 37 points|
|Tsitsipas overcomes Bautista Agut to continue Aus Open run|
|Barcelona move a ´dream come true´ for Boateng|