Northampton Saints and Leicester Tigers will meet in a Premiership fixture at Twickenham to help raise money for retired centre Rob Horne.
Horne was forced to call a halt to his career after suffering nerve damage to his right arm while playing for Saints against the Tigers at Welford Road in April.
The 28-year-old - who scored eight tries in 21 appearances for the English club - has since returned home to Australia with his family to undergo further treatment.
However, he will be in attendance on October 6 in the first league meeting of the two fierce rivals at Twickenham since the 2013 Premiership final.
"Everyone at the club has gone above and beyond to support me and my family through an incredibly difficult time," Horne - who won 34 caps for the Wallabies - told Northampton's website.
"I've been humbled by the outpouring of support from both Northampton Saints supporters and many of the Tigers fans that were at that game too.
"I am touched by the additional gesture the club are making in staging this game, and I can’t wait to see my team-mates run out at Twickenham.
"I hope we can raise some awareness for Brachial Plexus injuries, as well as being treated to another chapter in this storied rivalry."
The switch was made possible after the Rugby Football Union approached Saints about the possibility of hosting a home fixture at Twickenham to test the new East Stand development ahead of the 2018 autumn internationals.
"The outpouring of support for Rob at the end of last season from the whole rugby community in the East Midlands was overwhelming – and we wanted to act," said Saints chairman John White.
"Leicester Tigers' chairman and board have also made it clear that they are very keen to help Rob in any way they can, and this is a superb way to do that."
|Emery wanted Lacazette at Paris Saint-Germain|
|Wallabies centre Hodge suffers fractured ankle|
|Koepka claims top ranking with CJ Cup win|
|Dramatic Dovizioso crash gifts Marquez MotoGP title in Japan|
|LeBron´s home debut ends in defeat, Walker makes NBA history|
|Rondo, Ingram and Paul exchange punches in Lakers-Rockets clash|
|Dodgers to face Red Sox in World Series after beating Brewers|
|Valverde doesn´t care about extending Barca contract|
|Qualifying speed a ´positive surprise´ for Ferrari´s Vettel|
|I was in a different headspace – Hamilton revels in Austin pole|
|Barcelona can cope without Messi – Pique|
|Allegri: Juventus abandoned Genoa clash|
|Sale: Hospital visit was because of belly button ring|
|Valverde accepts Barcelona will miss Messi|
|No Messi or Ronaldo in El Clasico for first time since 2007|
|Barcelona have not won a Clasico without Messi since his debut|
|Ramos calls for Real Madrid unity after latest loss piles pressure on Lopetegui|
|Hamilton has title in sights after storming to Austin pole|
|Inter, El Clasico and more - the games Messi will miss with broken arm|
|End of Messi-Ronaldo duel good for LaLiga - Simeone|
|Messi out of Clasico with fractured arm|
|Awesome Ashton marks Sale bow with hat-trick|
|Klopp hopes for positive Henderson prognosis amid Liverpool injury issues|
|Benitez ´convinced´ Newcastle can survive despite seventh defeat|
|Barcelona 4 Sevilla 2: Messi injured but champions go top|
|Kovac relieved by Bayern´s timely victory|
|Strasbourg 2 Monaco 1: Sy howler and Grandsir red card cost Henry in first match|
|Leicester City defender Chilwell signs new six-year contract|
|PSG´s Tuchel hopes Verratti and Di Maria can face Napoli|
|Liverpool star Salah had no fear during scoring drought|
|Alonso´s 2019 plans not damaged by McLaren´s IndyCar decision|
|Edinburgh outclass troubled Toulon, Wasps and Bath play out thrilling draw|
|Barca concern as Messi substituted with worrying arm injury|
|Howe: South coast derby draw a fair result|
|Our heads were in Manchester – Allegri left fuming at Juventus´ loss of focus|
|Derby County 2 Sheffield United 1: Marriott blunts Blades with 77th-minute winner|
|We have so many problems – Jokanovic alarmed by Fulham defensive woes|
|Huddersfield Town 0 Liverpool 1: Salah snaps winless streak|
|Pellegrini ruing injuries after Yarmolenko hurts ankle|
|Villarreal 1 Atletico Madrid 1: Simeone´s side denied LaLiga top spot|
|Gracia: Not easy to dominate Wolves like that|
|Isner´s Finals hopes hindered by Stockholm defeat|
|Dyche incredulous at refereeing decisions in Man City thrashing|
|Juventus 1 Genoa 1: Champions´ winning run ends despite record Ronaldo goal|
|´Fantastic´ Lamela urged to find consistency by Pochettino|
|You don´t want to lose any players - Young speaks out on Wade NFL speculation|
|Championship Review: Smith gets off to a winning start, Leeds beaten|
|Guardiola hails extraordinary Fernandinho after Burnley drubbing|
|Pochettino lauds Lloris as one of world´s best after West Ham heroics|
|Paris Saint-Germain 5 Amiens 0: Ten wins in a row for PSG as Neymar rests|
|Cristiano Ronaldo nets record 400th league goal|
|Marcelo backing beleaguered Lopetegui despite Madrid slump|
|Garcia dazzles to hit the front at shortened Valderrama Masters|
|Cardiff City 4 Fulham 2: Paterson gets Bluebirds off the mark|
|Newcastle United 0 Brighton and Hove Albion 1: Benitez´s men bottom after dismal defeat|
|West Ham 0 Tottenham 1: In-form Lamela settles London derby|
|Manchester City 5 Burnley 0: De Bruyne returns in comfortable win|
|Wolves 0 Watford 2: Capoue and Pereyra turn form book on its head|
|Bournemouth 0 Southampton 0: Howe´s side stifled by Saints|
|Prove you´re crazy about Inter - Spalletti rallies players ahead of Milan derby|
|Wolfsburg 1 Bayern Munich 3: Lewandowski leads Kovac out of trouble|
|Goerges betters Bencic to clinch Luxembourg title|
|Morgan wants more from ´rusty´ England despite series win|
|Sarri says sorry after touchline bust-up overshadows Chelsea´s late escape|
|Chelsea draw an ´awful´ result for excellent United, says Mourinho|
|The Chelsea assistant that angered Mourinho - Who is Marco Ianni?|
|Steve Kerr supports Colin Kaepernick: ´I think he deserves a chance to play´|
|Lopetegui ´more motivated than ever´ amid Real Madrid sack reports|
|That´s football – Rudiger shrugs off late Ianni-Mourinho fracas|
|AC Milan´s improved mentality could be difference against Inter - Gattuso|